Yes, the Smurfs will be having a sequel for its first theatrical outing in 2011. The Smurfs 2 will basically see most of the cast reunited with the addition of the voice talents of Cristina Ricci and J.B. Smoove as the Naughties. The MediaFreaks 3D Animation Studio Blog refers you to the first official trailer for the Smurfs 2, scheduled for a release of July 31, 2013:
The sequel has been approved on the strength of its $563 million earnings worldwide. The film stars the voices of heavyweight Hollywood celebrities such as Neil Patrick Harris, Katy Perry and Sofia Vergara.